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15 Aug 2014
Causes of hyperthyroidism (hyperthyroidism) -  Toxic goiter is the most common cause of hyperthyroidism (hyperthyroidism) - 8 out of 10 cases - is toxic goiter (Graves 'disease), or Graves' disease, Graves. As autoimmune thyroiditis (Hashimoto), Graves is an autoimmune disease, and therefore is often inherited and associated with other autoimmune diseases.

Often, autoimmune thyroiditis and Graves' disease are observed in the same family, which can speak of a single gene or group of genes responsible for the development of these diseases. The disease occurs most frequently in aged 20 - 40 years, but there are cases in 5 years of age and even newborn.

The disease was first described by Robert James Graves in 1835 in Dublin (Ireland), and in 1840, the German physician Carl Adolf von Basedow in Merseburg (Germany) ("Merseburg triad Grave" - exophthalmos, tachycardia, and goiter). It is believed that the mechanism for the development of the autoimmune process in diffuse toxic goiter is to develop specific immune system antibodies to TSH receptor on thyroid cells.

In this iron resides in a state of high activity, which leads to an increase in its concentration of hormone in the blood. The reason for the formation of these antibodies remains unclear. According to one hypothesis, in patients who are predisposed to developing the disease, there are "wrong" to TSH receptors, which are detected by the immune system as "foreign."


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